Fishing the Big Sky Country

The three rivers that create the Missouri cover a large area of western Montana they all come togeather in Three Forks, Mt. The West Gallatin begins south of Yellowstone park, the fishing is excellent after spring run off until the middle of Aug. There is about a 2-3 month slow down period then as the water gets warm and low due to irrigation. The other half of the Gallatin River is the East Gallatin created by numerous small streams that drain the Bridgers, Hylite canyon and the Horseshoe Hills. The trout fishing is excellent from spring to late fall, the creeks and river have a mix of Rainbow, Brown trout, Brook trout and Whitefish.The Madison River is one the the hot spots for floaters.

During the spring Salmon Fly Hatch the fishing is great for Rainbow and Brown Trout.Travelers come from all over the state for the hatch.The Madison also has its slow time because of the water temperature.The Jefferson River starts in Twin Bridges, Mt where the Ruby, Big Hole, and the Beaverhead all came together. The Jefferson runs the most water of the three so it is fishable all most all year.The fishing is good for Rainbows, Browns and Whitefish. The three rivers are all considered to be excellent waters for the Fly Fisherman as well as bait, lures and spinners.

Anglers come from all over to fish the Headwaters of the Missouri and its tributaries. the Spring and fall bring an assortment of hatches so the Fly Fisherman has a large selection of flys that will work, dry and wet, Also there are Campgrounds where you can bring the family. Bait fishing all most all ways produces some fish regardless of the time of year. The Three Rivers are some of the most beautiful fishing waters in the state, some is easy to get to and some is truly an outdoor adventure.

Key Proteins to Combat Aging Discovered

The Global Challenge of Aging
The world is experiencing a significant demographic shift, with the number of individuals aged 60 and over projected to nearly double by 2050. This shift presents a substantial public health challenge, as aging populations are more susceptible to non-communicable diseases like heart disease, cancer, and diabetes. These conditions have overtaken infectious and parasitic diseases as the leading causes of death among the elderly, even in developing countries. Consequently, unraveling the mysteries of aging is not just a scientific pursuit but a necessity for public health.

Unraveling the Mechanism of Aging
Aging is characterized by the damage that cells incur over time due to various stressors, impacting their ability to proliferate. The buildup of senescent cells—cells that have stopped dividing—in tissues can lead to organ degeneration and age-related diseases. Animal model studies have indicated that removing these senescent cells can slow aging and extend the period of good health.

Researchers from the Institut Pasteur and CNRS have made a significant discovery in this area. They have identified that the gradual loss of certain proteins causes proliferating cells to enter an irreversible state of aging. This protein depletion is an early event, making it a critical determinant of cellular aging.

The Role of CSB Protein in Aging
One of the key factors in this process is a protein known as CSB, which is linked to Cockayne syndrome. Individuals with this syndrome, who lack CSB protein or have a dysfunctional version, experience premature aging, photosensitivity, progressive neurological decline, and cognitive impairments. Previous research by Dr. Miria Ricchetti and her team at the Pasteur Institute has shown that CSB deficiency also leads to abnormal mitochondrial function in cells.

The new study builds on this knowledge, demonstrating that similar changes occur during cellular aging and are closely related to physiological aging. The depletion of CSB is driven by epigenetic modifications that prevent the protein’s expression at the DNA level. Interestingly, molecules identified by the researchers that can reverse cellular defects in Cockayne syndrome patients also appear to slow the aging process in normal cells.

Implications for Healthier Aging
Dr. Ricchetti’s work suggests a strong connection between accelerated aging seen in conditions like Cockayne syndrome and the normal aging process. The identification of CSB as a key player in combating cellular aging is a promising development. It could lead to interventions that target the protein’s depletion, potentially delaying the onset of age-related diseases and improving the quality of life for the aging population.

The Potential of Epigenetic Therapies
The discovery that epigenetic modifications are involved in the depletion of CSB protein opens up the possibility of developing therapies that could modify these changes. Epigenetic therapies have the potential to rejuvenate cells by restoring the expression of proteins like CSB, thereby mitigating the effects of aging.

Future Research Directions
Further research is needed to understand the full implications of CSB protein in aging and to develop targeted therapies. The study of epigenetics in aging is a rapidly evolving field, and continued advancements could lead to breakthroughs in how we approach age-related health issues.

For more information on the aging process and the role of proteins like CSB, you can explore resources from the National Institute on Aging and the Institut Pasteur.

In conclusion, the identification of key proteins involved in the aging process is a significant step forward in the quest to extend human healthspan. As the global population continues to age, the importance of this research cannot be overstated, with the potential to transform the way we understand and manage the aging process.

Inspired by a Stunning Olympic Summer

Here is the situation: I am 32. I ran marathons in 2010 and 2011, although “ran” would be stretching the point in the case of the first, and even the second involved a certain amount of what some may call walking. In fact, anyone would call it that. And crying, there was a bit of that too!!

Anyway, having finished my lasy one in April of last year, I gradually felt the slowing down of my body and reached a stage around 6 weeks ago where I basically ended up a couch potato letting middle age come early. That was until London 2012, which to my mind has been the single greatest event in my lifetime and the great driver in making me be more than the man I am. My aim- the Rio Olympics, and the marathon.

Outlandish? Probably!!!! But I cant think of anything I could achieve that would be more of a joy-inducer, and nothing would make me feel prouder than to represenet my country at the next games.

So this is entry 1, I am open to all suggestions as to how to approach this! I want help, I want ideas and I will not be left wanting for ridcule I am sure, but my first aim is to run 26 miles off the reel by Christmas. Then, 3 hour race by April 2013. Then its making that leap from good runner to really good club runner. From ther, i think I have got 2 years to get my time down. By all means enjoy yourselves and enjot my near-certain failure. But i hope to entertain you along the way whatever happens.

Mor Farah said in his Olympic interview that anyone can do it- its just down to grafting and hard work. Mo – I want to prove you right mate!!!